Bang H. Hoang, M.D.
Associate Professor
Musculoskeletal Oncology
Director, UC Irvine Multidisciplinary Sarcoma Center

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Email: bhhoang@uci.edu

Dr. Hoang's CV

Clinical Specialty:
Musculoskeletal Oncology

Clinical Interests:
Dr. Hoang is a tenure-track faculty in the Department of Orthopaedic Surgery and the Chao Family Comprehensive Cancer Center at UC Irvine. He is currently the Director of the UC Irvine Multidisciplinary Sarcoma Center and his interests include surgical management of bone and soft tissue tumors and general orthopedics. In this capacity, he may serve as a consultant to other physicians in the care of pediatric and adult musculoskeletal oncology patients. He is a diplomat of the National Board of Medical Examiners and is Board Certified by the American Board of Orthopaedic Surgery.

Research Interests:
Dr. Hoang is an active member of the American Academy of Orthopaedic Surgeons, American Association for Cancer Research, Orthopedic Research Society, Connective Tissue Oncology Society, Children’s Oncology Group, Southwest Oncology Group, Western Orthopedic Association, and California Orthopedic Association.

He has presented his research at many local, national, and international meetings on a variety of topics ranging from complex joint reconstruction to bone and soft tissue tumors. Of note, he was recently invited to give a lecture on bone and soft tissue sarcomas at the National Institutes of Health. He has authored several peer-reviewed publications and book chapters, including reviews on soft tissue sarcomas for the American Academy of Orthopedic Surgeons and bone sarcoma for Orthopedic Clinics of North America.

During medical school, Dr. Hoang was selected as a Howard Hughes Medical Institute Research Scholar and spent two years conducting growth factor research at the National Institutes of Health in Bethesda, Maryland. Subsequently, he received his Orthopaedic Surgery training from Case Western Reserve University under Dr. Victor Goldberg, a leader in the field of osteoarthritis and total joint replacement. During fellowship, he conducted genetic research in osteosarcoma, a common bone cancer in children, at the Pediatric Sarcoma Laboratory of Memorial Sloan-Kettering Cancer Center.

Due to his contributions, Dr. Hoang later received the Clinical Research Award from the Department of Surgery at MSKCC and the Young Investigator Award from the Children’s Oncology Group. His laboratory at UC Irvine recently received funding from the National Institutes of Health to investigate new ways to stop the growth of bone sarcomas.

As part of his North American Traveling Fellowship, Dr. Hoang has been invited to give lectures on musculoskeleletal oncology at many prestigious institutions, among which are Harvard Medical School, Thomas Jefferson University, John Hopkins, Darmouth, University of Rochester, and McGill University in Canada. He was recently invited as a guest editor to organize a sarcoma symposium by the journal Clinical Orthopaedics and Related Research.

Undergraduate Degree:
University of California, Irvine

Medical Degree:
UCLA School of Medicine

Residency:
Case Western Reserve University

Fellowship:
Memorial Sloan-Kettering Cancer Center, New York

Awards:
Faculty Teaching Award (Dept of Orthopaedics, UC Irvine)
New Investigator RecognitionAward (Orthopedic Research Society)
Young Investigator Award (Children’s Oncology Group)
Clinical Scientist Development Award (National Institutes of Health) Dean's Junior Clinician-Scientist Award (UCI College of Medicine) North American Traveling Fellowship (American Orthopaedic Association)

Board Certifications:
American Board of Orthopaedic Surgery

Publications:
Scientific Articles:

1. Chang, SC, Hoang, B, Thomas, JT., Vukicevic, S, Luyten, FP, Ryba, NJ, Kozak, CA, Reddi, AH, Moos, M Jr. Cartilage-derived morphogenetic proteins. New members of the transforming growth factor-beta superfamily predominantly expressed in long bones during human embryonic development. J. Biol. Chem. 262, 28227-34 (1994).

2. Hoang, B, Moos, M Jr., Vukicevic, S, Luyten, FP. Primary Structure and Tissue Distribution of FRZB, a Novel Protein Related to Drosophila Frizzled Suggest a Role in Skeletal Morphogenesis. J. Biol. Chem. 271: 26131-37 (1996).

3. Hoang, BH, Thomas, JT, Abdul-Karim, FW, Correia, KM, Conlon, RA, Luyten, F.P, Ballock, RT. Expression Pattern of Two Frizzled-Related Genes, Frzb-1 and Sfrp-1, During Mouse Embryogenesis Suggests a Role for Modulating Action of Wnt Family Members. Dev. Dyn. 212: 364-372 (1998).

4. Kennedy, JG, Donahue, JP, Hoang, BH, Boland, PJ. Vesicant characteristics of oxapliplatin following antecubital extravasation. Clin Oncol. 15:237-239 (2003).

5. Kennedy, JG, Donahue, JR, Hoang, BH, Aydin, H, Huvos, A, Morris, C. Metastatic breast carcinoma to bone disguised by osteopoikiliosis. Skel. Radiol. 32:240-243 (2003).

6. Hoang, BH, Kubo, T, Healey, JH, Sowers, R, Mazza, B, Yang, R, Huvos, AG, Meyers, PA, Gorlick, R. Expression of LDL Receptor-Related Protein 5 (LRP5) as a Novel Marker for Disease Progression in High-Grade Osteosarcoma. Int J Cancer. 109:106-11 (2004).

7. Hoang, BH, Kubo, T, Healey, JH, Yang, R, Nathan, SS, Mazza, B, Meyers, PA, Gorlick, R. Dkk-3 Inhibits Invasion and Motility of Saos-2 Osteosarcoma Cells by Modulating the Wnt-Beta-Catenin Pathway. Cancer Res. 64:2734-9 (2004).

8. Hoang, BH, Dyke, JP, Koutcher, JA, Mizobuchi, H, Huvos, AG, Mazza, B, Meyers, PA, Gorlick, R, Healey, JH. VEGF Expression in Osteosarcoma Correlates with Vascular Permeability by Dynamic MRI. Clin Orthop Relat Res. 426:32-8 (2004).

9. Laverdiere, C, Hoang, BH, Yang, R, Sowers, R, Qin J, Meyers, PA, Huvos, AG, Healey, JH, Gorlick, R. Messenger RNA Expression Levels of CXCR4 Correlates with Metastatic Behavior and Outcome in Patients with Osteosarcoma. Clin Cancer Res. 11:2561-7 (2005).

10. Nathan, SS, DiResta, GR, Casas-Ganem, EJ, Hoang, BH, Sowers, R, Yang, R, Huvos, AG. Gorlick, R, Healey, JH. Elevated Physiological Tumor Pressure Promotes Proliferation and Chemosensitivity in Human Osteosarcoma. Clin Cancer Res. 11:2389-97 (2005).

11. Nathan SS, Healey JH, Mellano D, Hoang B, Lewis I, Morris CD, Athanasian EA, Boland PJ. Survival in Patients Operated on for Pathologic Fracture: Implications for End-of-Life Orthopedic Care. J Clin Oncol. 23:6072-82 (2005).

12. Zi, X, Guo, Y, Simoneau, AR, Hope, C, Holcombe, RF, Hoang, BH. Expression of a secreted Wnt antagonist, Frzb/sFRP-3, in human androgen-independent prostate cancer PC-3 cells suppresses tumor growth and cellular invasiveness. Cancer Res. 65:9762-70 (2005).

13. Hammond, G, Gu, M, Tehranzadeh, J, Hoang, BH. Periprosthetic soft tissue recurrence of chondroblastoma after attempted en-bloc excision from the proximal humerus. Skel Radiol. 35:53-7 (2006).

14. Kuphal, S, Lodermeyer, S, Bataille, F, Schuierer, M, Hoang, BH, Bosserhoff, AK. Expression of Dickkopf genes is strongly reduced in malignant melanoma. Oncogene. 25:5027-36 (2006).

15. Shibuya TY, Wadhwa A, Nguyen K, Panossian A, Kim S, Wong H, Feinberg S, Damisah EC, Camilon RP, Hoang B. Linking of bone morphogenetic protein-2 to resorbable fracture plates for enhancing bone healing. The Lanryngoscope. 115:2232-7 (2006).

16. Yang R, Kolb EA, Qin J, Chou A, Sowers R, Hoang B, Healey JH, Huvos AG, Meyers PA, Gorlick R. The folate receptor alpha is frequently overexpressed in osteosarcoma samples and plays a role in the uptake of the physiologic substrate 5-methyltetrahydrofolate. Clin Cancer Res. 13:2557-67 (2007).

17. Keyak JH, Kaneko TS, Skinner HB, Hoang BH. The Effect of Simulated Metastatic Lesions on Proximal Femoral Strength. Clin Orthop. 459:139-45 (2007).

18. Guo Y, Zi X, Koontz Z, Kim A, Xie J, Gorlick R, Holcombe RF, Hoang BH. Blocking Wnt/LRP5 signaling by a soluble receptor modulates the epithelial to mesenchymal transition and suppresses Met and metalloproteinases in osteosarcoma Saos-2 cells. J Orthop Res. 25:964-71(2007).

19. Yang R, Hoang BH, Kubo T, Kawano H, Chou A, Sowers R, Huvos AG, Meyers PA, Healey JH, Gorlick R. Overexpression of parathyroid hormone type-1 receptor confers an aggressive phenotype in osteosarcoma. Int J Cancer. 121:943-54 (2007).

20. Guo Y, Xie J, Rubin E, Tang YX, Lin F, Zi X, Hoang BH. Frzb, a secreted Wnt antagonist, decreases growth and invasiveness of fibrosarcoma cells associated with inhibition of Met signaling. Cancer Res. 68:3350-60 (2008).

21. Yang R, Li WW, Hoang BH, Kim H, Banerjee D, Kheradpour A, Healey JH, Meyers PA, Bertino JR, Gorlick R. Quantitative correlation between promoter methylation and messenger RNA levels of the reduced folate carrier. BMC Cancer. 8:124 (2008).

22. Yang R, Qin J, Hoang BH, Healey JH, Gorlick R. Polymorphisms and Methylation of the Reduced Folate Carrier in Osteosarcoma. Clin Orthop Relat Res. 466:2046-2051 (2008).

23. Guo Y, Rubin E, Xie J, Zi X, Hoang BH. Dominant Negative LRP5 Decreases Tumorigenicity and Metastasis of Osteosarcoma. Clin Orthop Relat Res. 466:2039-2045 (2008).

24. Tang Y, Simoneau AR, Liao WX, Yi G, Hope C, Liu F, Li S, Xie J, Holcombe RF, Jurnak FA, Mercola D, Hoang BH, Zi X. WIF1, a Wnt pathway inhibitor, regulates SKP2 and c-myc expression leading to G1 arrest and growth inhibition of human invasive urinary bladder cancer cells. Mol Cancer Ther. 8:458-68 (2009).

Book Chapters:

1. Randall, RL and Hoang, BH. Musculoskeletal Oncology, in Skinner, HB (ed): Current Diagnosis and Treatment in Orthopaedics, 4th edition. New York, NY, McGraw-Hill (2006).

2. Hoang, BH. Investigational Therapies for Soft Tissue Sarcomas, Orthopaedic Knowledge Update, Musculoskeletal Tumors, American Academy of Orthopaedic Surgeons (2007).

Review Articles:

1. Kennedy JG, Frelinghuysen P, Hoang BH. Ewing sarcoma: current concepts in diagnosis and treatment. Curr Opin Pediatr. 15:53-7 (2003).

2. Haydon JB, Hoang, BH. Osteosarcoma: Basic Science and Clinical Implications. Orthop Clin North Am. 37:1-7 (2006).

3. Wolf JM, Athwal GS, Hoang B, Mehta S, Owens BD. Report from the 2007 AOA North American Traveling Fellowship. J Bone Joint Surg Am. 90:1160-4 (2008).

4. Healey JH, Hoang, BH. Cancer Biology - Lessons Learned From Sarcoma. Clin Orthop Relat Res. 466:2029-30 (2008).

Abstracts:

1. Hoang, B. H., Chang, S. C., Moos, M. Jr., Luyten, F. P. Clone 22, A novel Gene cloned from bovine articular cartilage. 1993 Annual Meeting of the Howard Hughes Medical Institute Research Scholars Program, Bethesda, MD.

2. Hoang, B. H., Moos, M. Jr., Vukicevich, S., Luyten, F. P. FRZB, a novel Frizzled-Related Gene involved in skeletal morphogenesis. 1994 Annual Meeting of the Howard Hughes Medical Institute Research Scholars Program, Bethesda, MD.

3. Hoang, B. H. Expression of FRZB, a Novel Gene in the Developing Rodent Limb. 1996 Cleveland Orthopaedic Society Annual Resident Research Competition, Cleveland, OH.

4. Hoang, B. H., Thomas, J. T., Abdul-Karim, F. W., Correia, K. M., Conlon, R. A., Luyten, F. P., Ballock, R. T. Expression Pattern of Frzb-1 During Mouse Embryogenesis Suggests a Role for Modulating Action of Wnt Family Members. Trans Ortho Res Soc. 23:7 (1998).

5. Hoang, B. H., Luyten, F. P., Ballock, R. T. Expression of FRZB, a Frizzled-Related Gene, in the Developing Rodent. J Bone Min Res. 12 (supp 1):312 (1997).

6. Hoang, B. H., Carter, J. R., Ballock, R. T., Haber, L., Getty, P. J., Makley, J. T. Periosteal Chondroma Revisited. Musculoskeletal Tumor Society Abstracts (2000).

7. Patel, M., Hoang, B. H., Getty, P. J. Treatment of Symptomatic Fibrous Dysplasia with Oral Alendronate. 2002 Annual Meeting of the Musculoskeletal Tumor Society, Toronto, Canada.

8. Mellano, D., Hoang, B.H., Lewis, I., Agati, G., Boland, P.J., Healey, J.H. Factors affecting survival of surgically treated patients with bony metastases from carcinomas. 12th International Symposium on Limb Salvage, Rio de Janeiro, Brazil, (2003).

9. Hoang, B. H., Kennedy, J.G., Athanasian, E., Boland, P.J., Morris, C., Healey, J.H. Allograft-prosthetic composites for reconstruction of the proximal humerus. 12th International Symposium on Limb Salvage, Rio de Janeiro, Brazil, (2003).

10. Hoang, B. H., Kubo, T., Healey, J. H., Sowers, R., Mazza, B., Yang, R., Huvos, A. G., Meyers, P. A., Gorlick, R. Expression and potential role of low-density lipoprotein receptor-related protein 5 (LRP5) and Wnt signaling components in osteosarcoma. Proc Amer Assoc for Cancer Res. 44:921 (2003).

11. Hoang, B. H., Kennedy, J. G., Athanasian, E. Boland, P. J., Morris, C., Healey, J. H. Allograft-prosthetic composites for reconstruction of the proximal humerus. Annual Meeting of the Association of Bone and Joint Surgeons, Paris, France (2003).

12. Hoang, B. H., Dyke, J. P., Koutcher, J., Huvos, A. G., Mazza, B., Meyers, P. A., Gorlick, R., Healey, J. H. VEGF Expression in Osteosarcoma Correlates with Vascular Permeability by Dynamic MRI. Musculoskeletal Tumor Society Abstracts (2003).

13. Hoang, B. H., Sowers, R., Mazza, B., Huvos, A. G., Yang, R., Meyers, P. A., Gorlick, R., Healey, J. H. Expression of LRP5 as a novel marker for disease progression in high-grade osteosarcoma. Musculoskeletal Tumor Society Abstracts (2003).

14. Hoang, B. H., Kubo, T., Healey, J. H., Sowers, R., Mazza, B., Yang, R., Huvos, A. G., Meyers, P. A., Gorlick, R. Wnt signaling in human osteosarcoma: Novel therapeutic targets? 2003 Annual Doris Duke Symposium, Memorial Sloan-Kettering Cancer Center, New York, NY.

15. Hoang, B. H., Kubo, T., Sowers, R., Yang, R., Nathan, S. S., Kolb, E. A., Mazza, B., Huvos, A. G., Meyers, P. A., Gorlick, R., Healey, J. H. Wnt Signaling in Osteosarcoma: Potential Novel Targets for Prevention of Tumor Metastasis. Trans Ortho Res Soc. 29 (2004).

16. Nathan, S. S., Diresta, G., Gorlick, R., Hoang, B. H., Yang, R., Sowers, R., Mazza, B., Healey, J. H. Elevated fluid pressure in osteosarcoma enhances proliferation and chemosensitivity. Proc Amer Assoc for Cancer Res. 45: (2004).

17. Yang, R., Sowers, R., Laverdiere, C., Hoang, B., Healey, J., Huvos, A., Meyers, P., Gorlick, R. Over-expression of Parathyroid Hormone/ Related Peptide Receptor I Correlates with Relapse/Metastases in Osteosarcoma Samples. Proc Amer Assoc for Cancer Res. 45: (2004).

18. Laverdiere C, Hoang BH, Yang R, Sowers R, Qin J, Meyers PA, Huvos AG, Healey JH, Gorlick R. CXCR4 expression in osteosarcoma correlates with metastatic behavior and outcome in patients. Proc Amer Assoc for Cancer Res. 45:407 (2004).

19. Nathan SS, Diresta GR, Casas-Ganem J, Hoang B, Mazza B, Sowers R, Yang R, Gorlick R, Healey JH. Elevated fluid pressure in osteosarcoma enhances proliferation and chemosensitivity. Proc Amer Assoc for Cancer Res.45:1140 (2004).

20. Hoang, B. H., Kubo, T., Healey, J. H., Yang, R., Nathan, S. S., Kolb, E. A., Mazza, B., Meyers, P. A., Gorlick, R. Inhibition of Wnt signaling blocks cellular invasion and motility of Saos-2 osteosarcoma cells. Proc Amer Assoc for Cancer Res. 45: (2004).

21. Dyke, J. P., Hoang, B. H., Koutcher, J. A., Huvos, A. G., Mizobuchi, H., Mazza, B., Meyer, P. A., Gorlick, R., Healey. J. H. VEGF Expression in Osteosarcoma Correlates with Vascular Permeability by Dynamic MRI. Int Soc Magn Res Med Abstract (2004).

22. Altaf, F. M., Hoang, B., Yoo, J. U., Johnstone, B. Dkk1 in chondrogenic differentiation. Trans Ortho Res Soc. 30: 1112 (2005).

23. Zi, X., Guo, Y., Simoneau, A., Hoang, B. H. Frzb decreases invasiveness of bone metastatic prostate cancer PC-3 cells by up-regulation of E-cadherin and down-regulation of MMP-9 via degradation of beta-catenin. Trans Ortho Res Soc. 30: 1986 (2005).

24. Nathan S. S., DiResta, G. R., Hoang, B., Casas-Ganem, J., Manoso, M. W., Mazza, B. A., Sowers, R., Yang, R., Gorlick, R., Healey, J. H. Simulated osetosarcoma fluid pressures replicate chemotherapy-induced necrosis – Novel insights into systems biology. Trans Ortho Res Soc. 30: 433 (2005).

25. Guo Y., Zi X., Koontz Z., Kim, A., Holcombe, R. F., Gorlick, R., Hoang, B. H. Mechanisms of LRP5-mediated invasion in Saos-2 osteosarcoma cells. Proc Amer Assoc for Cancer Res. 46: 378 (2005).

26. Zi, X., Simoneau, A., Guo, Y., Hoang, B. H. WIF-1 up-regulates expression of E-cadherin and down-regulates activities and expression of MMP-2 and 9, leading to inhibition of in vitro invasiveness and tumor growth of androgen-independent PC-3 cells. Proc Amer Assoc for Cancer Res. 46: 93 (2005).

27. Guo, Y., Zi, X., Koontz, Z., Kim, A., Xie, J., Tap, W., Eilber, F.C., Hoang, B. H. Targeting soft tissue sarcomas by a soluble LRP5 dominant-negative receptor. Connective Tissue Oncology Society Abstracts (2005).

28. Guo, Y., Zi, X., Xie, J., Sworder, B., Hoang, B. H. Soluble Wnt antgonists decreases proliferatrion, invasion, and tumorigenesis in soft tissue sarcoma. Trans Ortho Res Soc. 31 (2006).

29. Yang, R., Hoang, B., Sowers, R., Healey, J., Huvos, A., Meyers, P., Gorlick, R. Over-expression of parathyroid hormone type 1 receptor correlated with relapse and metastases in osteosarcoma. Proc Amer Assoc for Cancer Res. 47: 301 (2006).

30. Tang, Y., Simoneau, A. R., Guo, Y., Xie, J., Hoang, B. H., Zi, X. Overexpression of WIF-1 in human urinary bladder cancer cells induces G1 arrest and chemosensitivity, via inhibition of AKT activation and SKP-2 expression, and a resultant increase in p27/KIP1 expression. Proc Amer Assoc for Cancer Res. 47: 183 (2006).

31. Guo, Y., Zi, X., Xie, J., Sworder, B., Hoang, B. H. The role of secreted Wnt inhibitors in soft tissue sarcomas. Proc Amer Assoc for Cancer Res. 47: 183 (2006).

32. Keyak J. H., Kaneko T. S., Skinner H. B., Hoang B. H. The effect of simulated metastatic lytic lesions on proximal femoral strength. Musculoskeletal Tumor Society Abstracts (2006).

33. Guo, Y., Zi, X., Sworder, B., Xie, J., Tap, W., Eilber, F.C., Hoang, B. H. Overexpression of Frzb, a secreted Wnt antagonist, decreases invasion, motility, and tumorigenesis of soft tissue sarcomas. Connective Tissue Oncology Society Abstracts (2006).

34. Guo Y, Zi X, Sworder B, Hockert P, Xie J,Kirov I,, Hoang, BH. A Soluble Wnt Receptor Shows Anti-tumor Activity in Osteosarcoma. Connective Tissue Oncology Society Abstracts (2006).

35. Kaneko T.S., Skinner H.B., Hoang B.H., Keyak J.H: The Effect of Simulated Metastatic Lytic Lesions on Proximal Femoral Strength. Chao Family Comprehensive Cancer Center Conference (2006).

36. Marcus P., Sehgal V., Al-Ghazi M., Hoang B., Bhatia N., Skinner H., Ramsinghani N., Mandelkern M., Keyak J. Novel kyphoplasty/brachytherapy technique for the treatment of vertebral metastases: A mathematical modeling feasibility study. Chao Family Comprehensive Cancer Center Conference (2006).

37. Guo, Y., Zi, X., Sworder, B., Che, F., George, S., Xie, J., Hoang, B. H. A Soluble Wnt Inhibitor Exerts Anti-Tumor Effects in Soft Tissue Sarcomas by Modulating the Met Pathway. Trans Ortho Res Soc. 31 (2007).

38. Kaneko TS, Hoang BH, Skinner HB, Keyak JH: Finite element model evaluation of simulated metastatic lesions at the level of the lesser trochanter. Trans Orthop Res Soc 32:1767 (2007).

39. Guo, Y., Zi, X., Sworder, B., Xie, J., Hoang, B.H. Overexpression of secreted Wnt antagonists decreases invasion and tumorigenesis of soft tissue sarcomas. Proc Amer Assoc for Cancer Res. 48: 2041 (2007).

40. Lee, J.A., Hoang, B.H., Chou, A.J., Meyers, P.A., Healey, J.H., Gorlick, R.G. Expression of vascular endothelial growth factor correlates with chemotherapy response in osteosarcoma patients. Proc Amer Assoc for Cancer Res. 48: 3489 (2007).

41. Tang, Y., Simoneau, A.R., Guo, Y., Liao, W., Hope, C., Xie, J., Holcombe, R.F., Jurnak, F.A., Hoang, B.H., Zi, X. Recombinant WIF-1 domain protein up-regulates p27/KIP1 and p21/WAF-1 and inhibits cell proliferation of bladder cancer cells via G1 arrest. Proc Amer Assoc for Cancer Res. 48: 4377 (2007).

42. Marcus P, Sehgal V, Al-Ghazi M, Ramsinghani N, Hoang B, Bhatia N, Skinner H, Keyak J. (2007). Novel kyphoplasty/brachytherapy technique for the treatment of vertebral metastases: A Monte Carlo feasibility study. Med Physics 34:2475-2475 (2007).

43. Rubin, E., Guo, Y., Xie, J., Zi, X., Hoang, B.H. Wnt inhibitory factor-1 (WIF-1) decreases tumorigenesis and metastasis in osteosarcoma. Musculoskeletal Tumor Society Abstract (2007).

44. Keyak JH, Marcus PG, Al-Ghazi MS, Bhatia NN, Hoang BH, Skinner HB, Ramsinghani NS, Mandelkern MA, and Sehgal V: Feasibility of a Combined Kyphoplasty and Brachytherapy Procedure for Vertebrae with Metastases. Musculoskeletal Tumor Society Abstract (2007).

45. Tang Y, Simoneau AR, Guo Y, Liao W, Hope C, Xie J, Holcombe RF, Jurnak FA, Hoang BH, Zi X. Recombinant WIF-1 domain protein up-regulates p27/KIP1 and p21/WAF-1 and inhibits cell proliferation of bladder cancer cells via G1 arrest Proc Am Assoc Cancer Res. 48, (2007).

46. FRZB Inhibits Invasion and Tumorigenesis of Soft Tissue Sarcomas. Guo Y, Zi X, Rubin E, Xie J, Hoang BH. Wnt Meeting Abstract. La Jolla, CA (2007).

47. Tang Y, Simoneau AR, Guo Y, Liao WX, Hope C, Liu F, Li S, Xie J, Holcombe RF, Mercola D, Jurnak FA, Hoang BH, and Zi X. WIF-1 inhibits the in vitro and in vivo growth of human invasive urinary bladder cancer cells associated with induction of G1 arrest. Wnt Meeting Abstract. La Jolla, CA (2007).

48. Lee J, Zell J, Hoang BH. Analysis of Prognostic Factors in Ewing Sarcoma Using a Population-Based Cancer Registry. Musculoskeletal Tumor Society Abstract (2008).

49. Guo Y, Zi X, Hoang BH. Blocking the Metastasis-Associated Gene S100A4 Reduces Metastatic Potential of Osteosarcoma. Musculoskeletal Tumor Society Abstract (2008).

50. Keyak J, Kaneko T, Sehgal V, Skinner H, Al-Ghazi M, Hoang B, Ramsinghani N. Feasibility of Using Radioactive Bone Cement to Treat Vertebral Metastases. Trans Ortho Res Soc. Las Vegas, NV (2009).

51. Tang Y, Simoneau AR, Yi G, Xie J, Hoang BH, Zi X: Ectopic expression of Wnt inhibitory factor-1 (WIF1) in prostate cancer PC-3 cell line decreases cellular invasiveness and tumor growth associated with both in vitro and in vivo increased expression of E-cadherin and decreased expression of Vimentin. Am Urol Assoc Abstract. Chicago, IL (2009).

52. Wolf JM, Athwal G, Hoang B, Mehta S, Williams A, Owens BD. Knowledge of Levels of Evidence Criteria in Orthopaedic Residents. Am Acad Orthop Surg Abstract. Las Vegas, NV (2009).

53. Guo Y, Che F, Xie J, Zi X, Hoang BH. Blocking the Metastasis-Associated Gene S100A4 Reduces Metastatic Potential of Osteosarcoma. Trans Orthop Res Soc. Las Vegas, NV (2009).

Please visit our new Orthopaedic & Sports Medicine Center in Costa Mesa at:

1640 Newport Blvd., Suite 230
Costa Mesa, CA 92627
949-515-5210

www.sportsmedicine.uci.edu

Dr. Nitin Bhatia and Dr. Thay Lee were presented with the prestigious "Harold and Nancy Willingham Award for Outstanding Research Paper" at the meeting of the Western Orthopaedic Association this year. Drs. Bhatia and Lee presented their paper, entitled "Biomechanical Evaluation of Short-Segment Posterior Instrumentation with Crosslinks In An Unstable Human Burst Fracture Model".

The WOA, with more than 1,700 members, held it's 73rd annual meeting in Seattle, Washington.

Dr. Bhatia, an orthopaedic surgeon and Dr. Lee, a Ph.D Research Career Scientist/Biomedical Engineer, are on staff at University of California at Irvine.